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KMID : 1035220100020010014
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Korean Journal of Neuromuscular Disorders
2010 Volume.2 No. 1 p.14 ~ p.20
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Anti-Ganglioside Antibodies and Guillain-Barre Syndrome
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Kim Jong-Kuk
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Abstract
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Guillain-Barre syndrome (GBS) is a representative form of acute post-infectious immune mediated neuropathies. Anti-ganglioside antibodies play a core pathogenic role in the pathophysiology of major subtypes of GBS and Miller Fisher syndrome (MFS). Nerve injury mediated by anti-ganglioside antibodies is known to be associated with disruption of structural stability at node of Ranvier. It results in damage of voltage-gated sodium channel and conduction failure. Some types of antibodies such as GM1, GD1a, GalNAc-GD1a and GM1b are associated with pure motor variant of GBS. Anti-GQ1b antibody is found from MFS or GBS with ophthalmoplegia and anti-GT1a antibody is highly associated with bulbar palsy though they can cross react with each other. As in the study from China and Japan, anti-ganglioside antibodies are frequent in Korean GBS patients and correlated well with clinical manifestations.
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KEYWORD
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Guillain-Barre syndrome, Miller Fisher syndrome, Ganglioside, Campylobacter, GM1, GD1a, GQ1b
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